{"id":4039,"date":"2020-09-14T13:19:12","date_gmt":"2020-09-14T13:19:12","guid":{"rendered":"https:\/\/cpgworld.com\/?p=4039"},"modified":"2020-10-11T09:44:40","modified_gmt":"2020-10-11T09:44:40","slug":"lightening-and-whitening-with-arbu-white","status":"publish","type":"post","link":"https:\/\/cpgworld.com\/ar\/lightening-and-whitening-with-arbu-white\/","title":{"rendered":"\u062a\u0628\u064a\u064a\u0636 \u0648\u062a\u0641\u062a\u064a\u062d \u0645\u0639 \u0622\u0631\u0628\u0648 \u0648\u0627\u064a\u062a"},"content":{"rendered":"

Arbutin<\/strong><\/p>

\u0623\u0631\u0628\u0648\u062a\u064a\u0646 \u0647\u0648 \u0623\u062d\u062f \u0623\u0643\u062b\u0631 \u0639\u0648\u0627\u0645\u0644 \u062a\u0641\u062a\u064a\u062d \u0627\u0644\u0628\u0634\u0631\u0629 \u0648\u0625\u0632\u0627\u0644\u0629 \u062a\u0635\u0628\u063a\u0647\u0627 \u0627\u0646\u062a\u0634\u0627\u0631\u064b\u0627 \u0641\u064a \u062c\u0645\u064a\u0639 \u0623\u0646\u062d\u0627\u0621 \u0627\u0644\u0639\u0627\u0644\u0645. Arbutin \u060c \u0645\u0634\u062a\u0642 b-D-glucopyranoside \u0645\u0646 \u0627\u0644\u0647\u064a\u062f\u0631\u0648\u0643\u064a\u0646\u0648\u0646 \u060c \u0647\u0648 \u0645\u0631\u0643\u0628 \u0645\u0634\u062a\u0642 \u0645\u0646 \u0627\u0644\u0646\u0628\u0627\u062a\u0627\u062a \u0628\u0634\u0643\u0644 \u0637\u0628\u064a\u0639\u064a \u0645\u0648\u062c\u0648\u062f \u0641\u064a \u0627\u0644\u0623\u0648\u0631\u0627\u0642 \u0627\u0644\u0645\u062c\u0641\u0641\u0629 \u0644\u0639\u062f\u062f \u0645\u0646 \u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0646\u0628\u0627\u062a\u064a\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0639\u0646\u0628 \u0627\u0644\u062f\u0628 (Arctostaphylos uva-ursi) \u060c \u0627\u0644\u0639\u0646\u0628\u064a\u0629 \u060c \u0627\u0644\u062a\u0648\u062a \u0627\u0644\u0628\u0631\u064a \u060c \u0648\u0623\u0634\u062c\u0627\u0631 \u0627\u0644\u0643\u0645\u062b\u0631\u0649. Arbutin \u060c \u064a\u062b\u0628\u0637 \u0646\u0634\u0627\u0637 \u0627\u0644\u062a\u064a\u0631\u0648\u0632\u064a\u0646\u0627\u0632 \u0628\u0634\u0643\u0644 \u062a\u0646\u0627\u0641\u0633\u064a \u0648\u0644\u0643\u0646 \u0628\u062a\u0631\u0643\u064a\u0632\u0627\u062a \u063a\u064a\u0631 \u0633\u0627\u0645\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0628\u0637\u0631\u064a\u0642\u0629 \u062a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0627\u0644\u062c\u0631\u0639\u0629 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0635\u0628\u0627\u063a\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0632\u0631\u0639\u0629.18<\/a>. \u0643\u0645\u0627 \u0623\u0646\u0647 \u064a\u0645\u0646\u0639 \u0646\u0636\u062c \u0627\u0644\u0645\u064a\u0644\u0627\u0646\u0648\u0633\u0648\u0645 \u0648\u0647\u0648 \u0623\u0642\u0644 \u0633\u0645\u064a\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0635\u0628\u0627\u063a\u064a\u0629 \u0645\u0646 \u0627\u0644\u0647\u064a\u062f\u0631\u0648\u0643\u064a\u0646\u0648\u0646. \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u062a\u0631\u0643\u064a\u0632\u0627\u062a \u0627\u0644\u0623\u0639\u0644\u0649 \u0642\u062f \u062a\u0643\u0648\u0646 \u0623\u0643\u062b\u0631 \u0641\u0627\u0639\u0644\u064a\u0629 \u060c \u0625\u0644\u0627 \u0623\u0646 \u0647\u0646\u0627\u0643 \u0645\u062e\u0627\u0637\u0631 \u0623\u0643\u0628\u0631 \u0644\u0641\u0631\u0637 \u062a\u0635\u0628\u063a \u0645\u062a\u0646\u0627\u0642\u0636.<\/p>

\u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0630\u0627\u062a \u0627\u0644\u0634\u0648\u0627\u0647\u062f \u062d\u0648\u0644 \u0639\u0644\u0627\u062c \u0641\u0631\u0637 \u0627\u0644\u062a\u0635\u0628\u063a \u063a\u064a\u0631 \u0645\u062a\u0648\u0641\u0631\u0629. \u0648\u0645\u0639 \u0630\u0644\u0643 \u060c \u0641\u0642\u062f \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0623\u0646 \u0623\u0631\u0628\u0648\u062a\u064a\u0646 \u0623\u0642\u0644 \u0641\u0639\u0627\u0644\u064a\u0629 \u0645\u0646 \u062d\u0645\u0636 \u0627\u0644\u0643\u0648\u062c\u064a\u0643 \u0644\u0641\u0631\u0637 \u0627\u0644\u062a\u0635\u0628\u063a. Deoxyarbutin \u0647\u0648 \u0645\u0634\u062a\u0642 \u0645\u0648\u0636\u0639\u064a \u0645\u0631\u0643\u0628. \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0623\u0646 \u0644\u0647 \u062a\u062d\u0633\u0646\u064b\u0627 \u0645\u0633\u062a\u062f\u0627\u0645\u064b\u0627 \u0645\u0639\u0632\u0632\u064b\u0627 \u060c \u0648\u062a\u0641\u062a\u064a\u062d\u064b\u0627 \u0639\u0627\u0645\u064b\u0627 \u0644\u0644\u0628\u0634\u0631\u0629 \u060c \u0648\u0645\u0638\u0647\u0631\u064b\u0627 \u0623\u0645\u0627\u0646\u064b\u0627 \u064a\u0636\u0627\u0647\u064a \u0627\u0644\u0647\u064a\u062f\u0631\u0648\u0643\u064a\u0646\u0648\u0646.19<\/a>]

18. Maeda K, Fukuda M. Arbutin: Mechanism of its depigmenting action in human melanocyte culture. J Pharmacol Exp Ther. 1996;276:765\u20139. [PubMed<\/a>] [Google Scholar<\/a>]

19. Boissy RE, Visscher M, DeLong MA. DeoxyArbutin: A novel reversible tyrosinase inhibitor with effective in vivo<\/em> skin lightening potency. Exp Dermatol. 2005;14:601\u20138. [PubMed<\/a>] [Google Scholar<\/a>]

Kojec acid:<\/strong><\/p>

\u064a\u062a\u0645 \u062f\u0645\u062c \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0628\u062f\u0627\u0626\u0644 \u0641\u064a \u062d\u0645\u0636 \u0643\u0648\u062c\u064a\u0643 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 2-\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u0645\u064a\u062b\u064a\u0644. \u064a\u062a\u0645 \u062a\u0635\u0646\u064a\u0639 \u0628\u0639\u0636 \u0645\u0634\u062a\u0642\u0627\u062a \u062d\u0645\u0636 \u0627\u0644\u0643\u0648\u062c\u064a\u0643 \u0648\u062a\u0642\u064a\u064a\u0645\u0647\u0627 \u0644\u0642\u062f\u0631\u062a\u0647\u0627 \u0639\u0644\u0649 \u062a\u062b\u0628\u064a\u0637 \u0623\u0648\u0643\u0633\u064a\u062f\u064a\u0632 \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629 (DAAO). \u062a\u0639\u0645\u0644 \u0647\u0630\u0647 \u0627\u0644\u0646\u0638\u0627\u0626\u0631 \u0643\u0645\u062c\u0633\u0627\u062a \u062c\u0632\u064a\u0626\u064a\u0629 \u0645\u0641\u064a\u062f\u0629 \u0644\u0627\u0633\u062a\u0643\u0634\u0627\u0641 \u0645\u0648\u0642\u0639 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u062b\u0627\u0646\u0648\u064a \u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0645\u0643\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0641\u064a \u062a\u0635\u0645\u064a\u0645 \u0645\u062b\u0628\u0637\u0627\u062a \u0623\u0643\u062b\u0631 \u0641\u0639\u0627\u0644\u064a\u0629

27- M. Raje, et al.<\/em>Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase<\/strong><\/p>

Bioorg. Med. Chem. Lett., 23 (13) (2013), pp. 3910-3913<\/p>

\u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0633\u0628\u0628 \u062a\u0639\u0631\u0636 \u062c\u0644\u062f \u0627\u0644\u0625\u0646\u0633\u0627\u0646 \u0644\u0644\u0623\u0634\u0639\u0629 \u0641\u0648\u0642 \u0627\u0644\u0628\u0646\u0641\u0633\u062c\u064a\u0629 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0622\u0641\u0627\u062a \u0627\u0644\u062c\u0644\u062f\u064a\u0629 \u060c \u0645\u062b\u0644 \u062d\u0631\u0648\u0642 \u0627\u0644\u0634\u0645\u0633 \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062c\u0644\u062f \u0648\u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a \u060c \u0648\u0643\u0644\u0647\u0627 \u062a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0643\u062b\u0627\u0641\u0629 \u0648\u0643\u0645\u064a\u0629 \u0627\u0644\u0623\u0634\u0639\u0629 \u0641\u0648\u0642 \u0627\u0644\u0628\u0646\u0641\u0633\u062c\u064a\u0629 [28\u060c29]. \u064a\u0645\u0643\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 KA \u0643\u062d\u0627\u0645\u064a \u0644\u0644\u0623\u0634\u0639\u0629 \u0641\u0648\u0642 \u0627\u0644\u0628\u0646\u0641\u0633\u062c\u064a\u0629 \u060c \u0645\u0639 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u062d\u062f \u0645\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0645\u062b\u0628\u0637 \u0644\u0644\u062a\u064a\u0631\u0648\u0632\u064a\u0646\u0627\u0632 \u0644\u0641\u0631\u0637 \u0627\u0644\u062a\u0635\u0628\u063a [2 \u060c [30] \u060c [31] \u060c [32] \u060c [33] \u060c [34] \u060c [35] \u060c [36]]. \u062c\u0639\u0644\u062a \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0644\u0644\u0647\u064a\u062f\u0631\u0648\u0643\u064a\u0646\u0648\u0646 (HQ) \u0643\u0645\u0646\u0638\u0641 \u0644\u0644\u0628\u0634\u0631\u0629 \u0645\u0634\u0647\u0648\u0631 \u0645\u0646 KA \u0628\u062f\u064a\u0644\u0627\u064b \u0645\u0646\u0627\u0633\u0628\u064b\u0627 \u0641\u064a \u0645\u0633\u062a\u062d\u0636\u0631\u0627\u062a \u0627\u0644\u062a\u062c\u0645\u064a\u0644 [2\u060c37]. \u062a\u0635\u0641 \u0647\u0630\u0647 \u0627\u0644\u0645\u0631\u0627\u062c\u0639\u0629 \u0648\u062a\u0646\u0627\u0642\u0634 \u0627\u0644\u062a\u0637\u0628\u064a\u0642 \u0648\u0627\u0644\u0642\u062f\u0631\u0629 \u0627\u0644\u0639\u0627\u0644\u064a\u0629 \u0644\u0640 KA \u060c \u0643\u0639\u0627\u0645\u0644 \u062a\u0641\u062a\u064a\u062d \u0641\u064a \u0645\u0633\u062a\u062d\u0636\u0631\u0627\u062a \u0627\u0644\u062a\u062c\u0645\u064a\u0644 \u0648\u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0635\u062d\u064a\u0629<\/p>

28-M.A. Ebrahimzadeh, et al.<\/em>Correlation between sun protection factor and antioxidant activity, phenol and flavonoid contents of some medicinal plants<\/strong><\/p>

Iranian journal of pharmaceutical research: IJPR, 13 (3) (2014), p. 1041<\/p>

29-N.S. Pour, et al.<\/em>Sun protection for children: a review<\/strong><\/p>

J. Pediatr. Rev., 3 (1) (2015)<\/p>

2-M. SaeediAn Overview of Cosmetics and Toiletries<\/strong><\/p>

30-J. Cabanes, S. Chazarra, F. Garcia\u2013CarmonaKojic acid, a cosmetic skin whitening agent, is a slow<\/strong>\u2010<\/strong>binding inhibitor of catecholase activity of tyrosinase<\/strong><\/p>

J. Pharm. Pharmacol., 46 (12) (1994), pp. 982-985<\/p>

31-E.V. Curto, et al.<\/em>Inhibitors of mammalian melanocyte tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors<\/strong><\/p>

Biochem. Pharmacol., 57 (6) (1999), pp. 663-672<\/p>

33-K. Sasaki, F. YoshizakiNobiletin as a tyrosinase inhibitor from the peel of Citrus fruit<\/strong><\/p>

Biol. Pharm. Bull., 25 (6) (2002), pp. 806-808<\/p>

32-Y.M. Kim, et al.<\/em>Oxyresveratrol and hydroxystilbene compounds inhibitory effect on tyrosinase and mechanism of action<\/strong><\/p>

J. Biol. Chem., 277 (18) (2002), pp. 16340-16344<\/p>

34-M. Ishikawa, I. Kawase, F. IshiiCombination of amino acids reduces pigmentation in B16F0 melanoma cells<\/strong><\/p>

Biol. Pharm. Bull., 30 (4) (2007), pp. 677-681<\/p>

35-P. Donsing, N. Limpeanchob, J. ViyochEvaluation of the effect of Thai breadfruit\u2019s heartwood extract on melanogenesis-inhibitory and antioxidation activities<\/strong><\/p>

J. Cosmet. Sci., 59 (1) (2008), pp. 41-58<\/p>

36-O. Abdel-Halim, et al.<\/em>A new tyrosinase inhibitor from Crinum yemense as potential treatment for hyperpigmentation<\/strong><\/p>

Die Pharmazie-An International Journal of Pharmaceutical Sciences, 63 (5) (2008), pp. 405-407<\/p>

37-S. Emami, et al.<\/em>Kojic acid and its manganese and zinccomplexes as potential radioprotective agents<\/strong><\/p>

Bioorg. Med. Chem. Lett., 17 (1) (2007), pp. 45-48<\/p>

<\/p>","protected":false},"excerpt":{"rendered":"

Arbutin Arbutin is one of the most widely prescribed skin-lightening and de-pigmenting agent worldwide. Arbutin, the b-D-glucopyranoside derivative of hydroquinone, is a naturally occurring plant derived compound found in the dried leaves of a number of different plant species including, bearberry (Arctostaphylos uva-ursi), blueberry, cranberry, and pear trees. Arbutin, inhibits tyrosinase activity competitively but at
+ Read More<\/a><\/p>","protected":false},"author":1,"featured_media":3389,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[154],"tags":[136,147,152,86,149,148,150,146,151],"class_list":["post-4039","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medical-cosmetic-creams","tag-arbu-white","tag-arbutin","tag-coid","tag-corona","tag-kojec_acid","tag-kojecacid","tag-lightening","tag-white","tag-whitening"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/cpgworld.com\/wp-content\/uploads\/2020\/07\/\u0648\u0627\u064a\u062a-1.png","_links":{"self":[{"href":"https:\/\/cpgworld.com\/ar\/wp-json\/wp\/v2\/posts\/4039","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpgworld.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpgworld.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpgworld.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpgworld.com\/ar\/wp-json\/wp\/v2\/comments?post=4039"}],"version-history":[{"count":2,"href":"https:\/\/cpgworld.com\/ar\/wp-json\/wp\/v2\/posts\/4039\/revisions"}],"predecessor-version":[{"id":4046,"href":"https:\/\/cpgworld.com\/ar\/wp-json\/wp\/v2\/posts\/4039\/revisions\/4046"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpgworld.com\/ar\/wp-json\/wp\/v2\/media\/3389"}],"wp:attachment":[{"href":"https:\/\/cpgworld.com\/ar\/wp-json\/wp\/v2\/media?parent=4039"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpgworld.com\/ar\/wp-json\/wp\/v2\/categories?post=4039"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpgworld.com\/ar\/wp-json\/wp\/v2\/tags?post=4039"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}