{"id":4004,"date":"2020-09-12T12:12:43","date_gmt":"2020-09-12T12:12:43","guid":{"rendered":"https:\/\/cpgworld.com\/?p=4004"},"modified":"2020-10-11T09:44:10","modified_gmt":"2020-10-11T09:44:10","slug":"leucoderma","status":"publish","type":"post","link":"https:\/\/cpgworld.com\/ar\/leucoderma\/","title":{"rendered":"\u0644\u064a\u0648\u0643\u0648\u062f\u064a\u0631\u0645\u0627 - \u0643\u0631\u064a\u0645 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0628\u0647\u0627\u0642"},"content":{"rendered":"<p><strong><em>\u0645\u0633\u062a\u062e\u0644\u0635 \u0627\u0644\u0635\u0628\u0627\u0631<\/em><\/strong><\/p><p>\u0648\u062c\u062f\u062a \u062f\u0631\u0627\u0633\u0629 \u0623\u062c\u0631\u064a\u062a \u0639\u0644\u0649 \u0627\u0644\u062d\u064a\u0648\u0627\u0646\u0627\u062a \u0623\u0646 \u0645\u0633\u062a\u062e\u0644\u0635 \u0623\u0648\u0631\u0627\u0642 \u0646\u0628\u0627\u062a A. Vera \u0648\u0645\u0643\u0648\u0646\u0647 \u0627\u0644\u0646\u0634\u0637 Aloin \u064a\u0633\u0628\u0628\u0627\u0646 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u062a\u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u064a\u0644\u0627\u0646\u064a\u0646 \u0627\u0644\u0642\u0648\u064a\u0629 \u0648\u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0639\u0644\u0649 \u0627\u0644\u062c\u0631\u0639\u0629 \u0648\u0630\u0627\u062a \u0627\u0644\u0623\u0647\u0645\u064a\u0629 \u0627\u0644\u0641\u0633\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0641\u062a\u064a\u062d \u0627\u0644\u062c\u0644\u062f \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062d\u0641\u064a\u0632 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0623\u062f\u0631\u064a\u0646\u0627\u0644\u064a\u0629.<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3663177\/#ref32\">32<\/a>\u0645\u0633\u062a\u062e\u0644\u0635 \u0627\u0644\u0635\u0628\u0627\u0631 \u0647\u0648 \u0623\u062d\u062f \u0645\u0643\u0648\u0646\u0627\u062a \u0645\u0633\u062a\u062d\u0636\u0631\u0627\u062a \u0627\u0644\u0633\u0648\u0642 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629<\/p><p>32.&nbsp;Ali SA, Galgut JM, Choudhary RK. On the novel action of melanolysis by a leaf extract of Aloe vera and its active ingredient aloin, potent skin depigmenting agents.&nbsp;Planta Med.&nbsp;2012;78:767\u201371.&nbsp;[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22495441\">PubMed<\/a>]&nbsp;[<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Planta+Med&amp;title=On+the+novel+action+of+melanolysis+by+a+leaf+extract+of+Aloe+vera+and+its+active+ingredient+aloin,+potent+skin+depigmenting+agents&amp;author=SA+Ali&amp;author=JM+Galgut&amp;author=RK+Choudhary&amp;volume=78&amp;publication_year=2012&amp;pages=767-71&amp;pmid=22495441&amp;\">Google Scholar<\/a>]<h3 class=\"wp-block-heading\"><em>\u0623\u0644\u0641\u0627 \u062a\u0648\u0643\u0648\u0641\u064a\u0631\u0648\u0644 (\u0641\u064a\u062a\u0627\u0645\u064a\u0646 \u0647\u0640)<\/em><\/h3><p>\u0641\u064a\u062a\u0627\u0645\u064a\u0646 (\u0647\u0640) \u0647\u0648 \u0623\u062d\u062f \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0623\u0643\u0633\u062f\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0627\u0644\u0645\u062d\u0628\u0629 \u0644\u0644\u062f\u0647\u0648\u0646 \u0641\u064a \u0627\u0644\u0628\u0644\u0627\u0632\u0645\u0627 \u0648\u0627\u0644\u0623\u063a\u0634\u064a\u0629 \u0648\u0627\u0644\u0623\u0646\u0633\u062c\u0629. \u064a\u0634\u0645\u0644 \u0645\u0635\u0637\u0644\u062d \"\u0641\u064a\u062a\u0627\u0645\u064a\u0646 \u0625\u064a\" \u062b\u0645\u0627\u0646\u064a\u0629 \u062c\u0632\u064a\u0626\u0627\u062a \u0637\u0628\u064a\u0639\u064a\u0629 (\u0623\u0631\u0628\u0639\u0629 \u062a\u0648\u0643\u0648\u0641\u064a\u0631\u0648\u0644 \u0648\u0623\u0631\u0628\u0639\u0629 \u062a\u0648\u0643\u0648\u062a\u0631\u064a\u0646\u0648\u0644) \u0627\u0644\u062a\u064a \u0644\u0647\u0627 \u0646\u0634\u0627\u0637 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 \u0647\u0640. \u0641\u064a \u0627\u0644\u0628\u0634\u0631 \u060c \u0623\u0644\u0641\u0627 \u062a\u0648\u0643\u0648\u0641\u064a\u0631\u0648\u0644 \u0647\u0648 \u0623\u0643\u062b\u0631 \u0645\u0634\u062a\u0642\u0627\u062a \u0641\u064a\u062a\u0627\u0645\u064a\u0646 \u0625\u064a \u0648\u0641\u0631\u0629 \u060c \u064a\u0644\u064a\u0647 \u062c\u0627\u0645\u0627 \u062a\u0648\u0643\u0648\u0641\u064a\u0631\u0648\u0644<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3663177\/#ref25\">25<\/a>]<p>\u062a\u0638\u0647\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062e\u0627\u0636\u0639\u0629 \u0644\u0644\u0631\u0642\u0627\u0628\u0629 \u0645\u0639 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 \u0647\u0640 \u0623\u062f\u0644\u0629 \u063a\u064a\u0631 \u0643\u0627\u0641\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u062c\u0644\u062f\u064a\u0629 \u0645\u0639\u064a\u0646\u0629. \u0648\u0645\u0639 \u0630\u0644\u0643 \u060c \u0647\u0646\u0627\u0643 \u0645\u062c\u0645\u0648\u0639\u0629 \u0643\u0628\u064a\u0631\u0629 \u0645\u0646 \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062b\u0628\u062a \u0622\u062b\u0627\u0631\u0647\u0627 \u0627\u0644\u0648\u0627\u0642\u064a\u0629 \u0645\u0646 \u0627\u0644\u0636\u0648\u0621. \u0648\u0642\u062f \u062b\u0628\u062a \u0623\u0646\u0647 \u064a\u0633\u0628\u0628 \u0625\u0632\u0627\u0644\u0629 \u0627\u0644\u062a\u0635\u0628\u063a \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u062a\u062f\u0627\u062e\u0644 \u0645\u0639 \u0628\u064a\u0631\u0648\u0643\u0633\u064a\u062f \u0627\u0644\u062f\u0647\u0648\u0646 \u0641\u064a \u0623\u063a\u0634\u064a\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0635\u0628\u0627\u063a\u064a\u0629 \u060c \u0648\u0632\u064a\u0627\u062f\u0629 \u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u062c\u0644\u0648\u062a\u0627\u062b\u064a\u0648\u0646 \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u060c \u0648\u062a\u062b\u0628\u064a\u0637 \u0627\u0644\u062a\u064a\u0631\u0648\u0632\u064a\u0646\u0627\u0632.<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3663177\/#ref26\">26<\/a>\u0623\u0638\u0647\u0631\u062a \u062f\u0631\u0627\u0633\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0623\u062e\u0631\u0649 \u0645\u0632\u062f\u0648\u062c\u0629 \u0627\u0644\u062a\u0639\u0645\u064a\u0629 \u062a\u062d\u0633\u0646\u064b\u0627 \u0645\u0644\u062d\u0648\u0638\u064b\u0627 \u0641\u064a \u0622\u0641\u0627\u062a \u0627\u0644\u0643\u0644\u0641 \u0648\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u062c\u0644\u062f \u0627\u0644\u062a\u0645\u0627\u0633\u064a \u0627\u0644\u0645\u0635\u0637\u0628\u063a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0641\u064a\u062a\u0627\u0645\u064a\u0646\u0627\u062a E \u0648 C \u0627\u0644\u0645\u0648\u0636\u0639\u064a\u0629 \u060c \u0645\u0639 \u0638\u0647\u0648\u0631 \u0646\u062a\u0627\u0626\u062c \u0623\u0641\u0636\u0644 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0641\u064a\u062a\u0627\u0645\u064a\u0646 \u0648\u0627\u062d\u062f.<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3663177\/#ref27\">27<\/a>\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 alpha-tocopherol \u0627\u0644\u0645\u0648\u0636\u0639\u064a \u064a\u0633\u062a\u062e\u062f\u0645 \u0641\u064a \u0627\u0644\u063a\u0627\u0644\u0628 \u0628\u062a\u0631\u0643\u064a\u0632 5\u066a \u0623\u0648 \u0623\u0642\u0644 \u060c \u0641\u0642\u062f \u062a\u0645 \u062a\u0633\u0648\u064a\u0642 \u0627\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0630\u0627\u062a \u0627\u0644\u062a\u0631\u0643\u064a\u0632\u0627\u062a \u0627\u0644\u0645\u062a\u0641\u0627\u0648\u062a\u0629. \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0645\u062b\u0644 \u0631\u062f\u0648\u062f \u0627\u0644\u0641\u0639\u0644 \u0627\u0644\u062a\u062d\u0633\u0633\u064a\u0629 \u0623\u0648 \u0627\u0644\u0645\u0647\u064a\u062c\u0629 \u0646\u0627\u062f\u0631\u0629 \u0645\u0639 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 E \u0627\u0644\u0645\u0648\u0636\u0639\u064a \u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0641\u0647\u0648 \u0623\u062d\u062f \u0645\u0643\u0648\u0646\u0627\u062a \u0645\u0633\u062a\u062d\u0636\u0631\u0627\u062a \u0627\u0644\u062a\u062c\u0645\u064a\u0644<\/p><p>25.&nbsp;Thiele JJ, Hsieh SN, Ekanayake-Mudiyanselage S. Vitamin E: Critical review of its current use in cosmetic and clinical dermatology.&nbsp;Dermatol Surg.&nbsp;2005;31:805\u201313.&nbsp;[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16029671\">PubMed<\/a>]&nbsp;[<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Dermatol+Surg&amp;title=Vitamin+E:+Critical+review+of+its+current+use+in+cosmetic+and+clinical+dermatology&amp;author=JJ+Thiele&amp;author=SN+Hsieh&amp;author=S+Ekanayake-Mudiyanselage&amp;volume=31&amp;publication_year=2005&amp;pages=805-13&amp;pmid=16029671&amp;\">Google Scholar<\/a>]<p>26.&nbsp;Badreshia-Bansal S, Draelos ZD. Insight into skin lightening cosmeceuticals for women of color.&nbsp;J Drugs Dermatol.&nbsp;2007;6:32\u20139.&nbsp;[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17373159\">PubMed<\/a>]&nbsp;[<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J+Drugs+Dermatol&amp;title=Insight+into+skin+lightening+cosmeceuticals+for+women+of+color&amp;author=S+Badreshia-Bansal&amp;author=ZD+Draelos&amp;volume=6&amp;publication_year=2007&amp;pages=32-9&amp;pmid=17373159&amp;\">Google Scholar<\/a>]<p>27.&nbsp;Hayakawa R, Ueda H, Nozaki T, Izawa Y, Yokotake J, Yazaki K, et al. Effects of combination treatment with vitamins E and C on chloasma and pigmented contact dermatitis. A double blind controlled clinical trial.&nbsp;Acta Vitaminol Enzymol.&nbsp;1981;3:31\u20138.&nbsp;[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7027767\">PubMed<\/a>]&nbsp;[<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Acta+Vitaminol+Enzymol&amp;title=Effects+of+combination+treatment+with+vitamins+E+and+C+on+chloasma+and+pigmented+contact+dermatitis.+A+double+blind+controlled+clinical+trial&amp;author=R+Hayakawa&amp;author=H+Ueda&amp;author=T+Nozaki&amp;author=Y+Izawa&amp;author=J+Yokotake&amp;volume=3&amp;publication_year=1981&amp;pages=31-8&amp;pmid=7027767&amp;\">Google Scholar<\/a><\/p><p><strong><em><u>\u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a \u0628\u062e\u0644\u0627\u0635\u0629 \u0627\u0644\u0632\u0639\u062a\u0631 :<\/u><\/em><\/strong><em><u><\/u><\/em><\/p><p>\u064a\u0645\u062a\u0644\u0643 \u0627\u0644\u0632\u064a\u062a \u0627\u0644\u0639\u0637\u0631\u064a \u0627\u0644\u0645\u0633\u062a\u062e\u0631\u062c \u0645\u0646 \u0627\u0644\u0632\u0639\u062a\u0631 \u0648\u0645\u0643\u0648\u0646\u0647 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0627\u0644\u062b\u064a\u0645\u0648\u0644 \u0645\u062c\u0645\u0648\u0639\u0629 \u0648\u0627\u0633\u0639\u0629 \u0645\u0646 \u0627\u0644\u0646\u0634\u0627\u0637 \u0636\u062f \u0623\u0646\u0648\u0627\u0639 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0648\u0627\u0644\u0641\u0637\u0631\u064a\u0627\u062a \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0632\u064a\u0648\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u0641\u064a \u0643\u0644 \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u064a\u0629 \u0648\u0627\u0644\u062d\u064a\u0648\u064a\u0629.<sup>31,32,33,34&nbsp;<\/sup>\u0623\u0634\u0627\u0631\u062a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0625\u0644\u0649 \u0623\u0646 \u0627\u0644\u0632\u0639\u062a\u0631 \u0648 \u0627\u0644\u062b\u064a\u0645\u0648\u0644 \u0644\u0647 \u0623\u0646\u0634\u0637\u0629 \u0642\u0648\u064a\u0629 \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a \u0636\u062f \u0623\u0646\u0648\u0627\u0639 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0645\u062b\u0644 Helicobacter pylori \u060c Salmonella typhimurium \u060c Staphylococcus aureus \u060c Selenomonasartemidis \u060c Porphyromonas gingivalis \u060c Streptococcus mutans \u0648 Streptococcus<sup>35,36&nbsp;<\/sup>\u0645\u0645\u0627 \u064a\u0633\u0628\u0628 \u062a\u062f\u0641\u0642 \u0627\u0644\u0645\u0643\u0648\u0646\u0627\u062a \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627. \u0648\u0628\u0627\u0644\u0645\u062b\u0644 \u060c \u0623\u0641\u0627\u062f\u062a \u062f\u0631\u0627\u0633\u0627\u062a \u0623\u062e\u0631\u0649 \u0628\u0648\u062c\u0648\u062f \u0646\u0634\u0627\u0637 \u0642\u0648\u064a \u0645\u0636\u0627\u062f \u0644\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0645\u0646 \u0627\u0644\u062b\u064a\u0645\u0648\u0644 \u0636\u062f \u0623\u0646\u0648\u0627\u0639 \u0645\u0639\u064a\u0646\u0629 \u0645\u0646 \u0627\u0644\u0641\u0637\u0631\u064a\u0627\u062a \u0648\u0627\u0644\u062e\u0645\u064a\u0631\u0629 \u0645\u062b\u0644 Aspergillus flavus \u0648 Aspergillus Pariticus \u0648 Candida albicans. 37 \u060c&nbsp;<em>Aspergillus flavus<\/em>,&nbsp;<em>Aspergillus parasiticus<\/em>&nbsp;and<em>&nbsp;Candida albicans<\/em>.<sup>&nbsp;37,38<\/sup><\/p><p>\u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643 \u060c&nbsp;<em>Marino et al.<\/em><sup>39<\/sup>&nbsp;\u0632\u064a\u0648\u062a \u0627\u0644\u0632\u0639\u062a\u0631 \u0644\u062e\u0635\u0627\u0626\u0635\u0647\u0627 \u0627\u0644\u0645\u062b\u0628\u0637\u0629 \u0644\u0644\u0646\u0645\u0648 \u0636\u062f \u0633\u0644\u0627\u0644\u0627\u062a \u0645\u0639\u064a\u0646\u0629 \u0645\u0646 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0633\u0627\u0644\u0628\u0629 \u0627\u0644\u062c\u0631\u0627\u0645 \u0648\u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0627\u0644\u062c\u0631\u0627\u0645. \u0644\u0648\u062d\u0638 \u0623\u0646 \u062c\u0645\u064a\u0639 \u0632\u064a\u0648\u062a \u0627\u0644\u0632\u0639\u062a\u0631 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0645 \u0641\u062d\u0635\u0647\u0627 \u0644\u0647\u0627 \u062a\u0623\u062b\u064a\u0631 \u0642\u0648\u064a \u0645\u0636\u0627\u062f \u0644\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a \u0636\u062f \u0643\u0644\u0627 \u0627\u0644\u0646\u0648\u0639\u064a\u0646 \u0645\u0646 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627. \u064a\u0639\u062a\u0628\u0631 \u0627\u0644\u0632\u064a\u062a \u0627\u0644\u0639\u0637\u0631\u064a \u0644\u0644\u062a\u0644\u0641\u0632\u064a\u0648\u0646 \u0641\u0639\u0627\u0644\u0627\u064b \u0644\u0644\u063a\u0627\u064a\u0629 \u0641\u064a \u0645\u0646\u0639 \u0646\u0645\u0648 \u0623\u0646\u0648\u0627\u0639 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627. \u0623\u0638\u0647\u0631\u062a \u062f\u0631\u0627\u0633\u0629 \u0625\u0636\u0627\u0641\u064a\u0629 \u0623\u062c\u0631\u0627\u0647\u0627&nbsp;<em>Nolkemper et al.<\/em><sup>40<\/sup>&nbsp;\u0623\u0646 \u0647\u0630\u0627 \u0627\u0644\u0632\u064a\u062a \u0623\u0638\u0647\u0631 \u062a\u0623\u062b\u064a\u0631\u064b\u0627 \u0645\u062b\u0628\u0637\u064b\u0627 \u0636\u062f \u0623\u0646\u0648\u0627\u0639 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0645\u062b\u0644 \u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0647\u0631\u0628\u0633 \u0627\u0644\u0628\u0633\u064a\u0637 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 1 (HSV-1) \u0648\u0633\u0644\u0627\u0644\u0629 \u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0623\u0633\u064a\u0643\u0644\u0648\u0641\u064a\u0631 \u0645\u0646 HSV-1.<\/p><p><strong><em>\u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0623\u0643\u0633\u062f\u0629 \u0648\u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0645\u0646 TVEO<\/em><\/strong><em><\/em><\/p><p>\u0641\u064a \u0627\u0644\u0646\u0645\u0627\u0630\u062c \u0627\u0644\u062d\u064a\u0648\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u064a\u0629&nbsp;<em>in vitro&nbsp;<\/em>\u060c \u062a\u0628\u064a\u0646 \u0623\u0646 \u0632\u064a\u062a \u0627\u0644\u0632\u0639\u062a\u0631 \u0648\u0627\u0644\u062b\u064a\u0645\u0648\u0644 \u064a\u0638\u0647\u0631\u0627\u0646 \u0623\u0646\u0634\u0637\u0629 \u0642\u0648\u064a\u0629 \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0623\u0643\u0633\u062f\u0629. \u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643 \u060c \u062a\u0645 \u0625\u062b\u0628\u0627\u062a \u0623\u0646 \u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0641\u0644\u0627\u0641\u0648\u0646\u0648\u064a\u062f \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u062a\u0645\u0646\u0639 \u0625\u0637\u0644\u0627\u0642 \u0623\u0646\u064a\u0648\u0646 \u0641\u0627\u0626\u0642 \u0627\u0644\u0623\u0643\u0633\u064a\u062f \u0648\u062a\u062d\u0645\u064a \u0643\u0631\u064a\u0627\u062a \u0627\u0644\u062f\u0645 \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0645\u0646 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a. \u064a\u0645\u0627\u0631\u0633 \u0627\u0644\u062b\u064a\u0645\u0648\u0644 \u0648\u0627\u0644\u0643\u0627\u0631\u0627\u0643\u0648\u0644 \u0623\u064a\u0636\u064b\u0627 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062b\u0628\u064a\u0637 \u062a\u062e\u0644\u064a\u0642 \u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u062c\u0644\u0627\u0646\u062f\u064a\u0646<sup>&nbsp;41, 42, 43, 44<\/sup><\/p><p>31.Lai P. K and Roy J. Antimicrobial and chemopreventive properties of herbs and spices. Current medicinal chemistry, 2004; 11(11): 1451-1460.\u200f<\/p><p>32.Mitsch P, Zitterl-Eglseer K, K\u00f6hler B, Gabler C, Losa R and Zimpernik I. The effect of two different blends of essential oil components on the proliferation of Clostridium perfringens in the intestines of broiler chickens. Poultry science, 2004; 83(4): 669-675.\u200f<\/p><p>33.Penalver P, Huerta B, Borge C, Astorga R, Romero R and Perea A. Antimicrobial activity of five essential oils against origin strains of the Enterobacteriaceae family. Apmis, 2005; 113(1): 1-6.\u200f<\/p><p>34.Al-Bayati F. A. Synergistic antibacterial activity between Thymus vulgaris and Pimpinellaanisum essential oils and methanol extracts. Journal of ethnopharmacology, 2008; 116(3): 403-406.\u200f<\/p><ul class=\"wp-block-list\"><li>&nbsp;Manou I, Bouillard L, Devleeschouwer M. J and Barel A. O. Evaluation of the preservative properties of Thymus vulgaris essential oil in topically applied formulations under a challenge test. Journal of Applied Microbiology, 1998; 84(3): 368-376.\u200f<\/li><li>&nbsp;Ceyhan N and Ugur A. Investigation of in vitro antimicrobial activity of honey. Rivista di biologia, 2001; 94(2): 363-371.\u200f<\/li><li>&nbsp;Arras G and Usai M. Fungitoxic activity of 12 essential oils against four postharvest citrus pathogens: chemical analysis of Thymus capitatus oil and its effect in subatmospheric pressure conditions. Journal of Food Protection, 2001; 64(7): 1025-1029.\u200f<\/li><li>Inouye S, Uchida K and Yamaguchi H. In vitro and in vivo anti Trichophyton activity of essential oils by vapour contact. Mycoses, 2001; 44(3\u20104): 99-107.\u200f<\/li><li>Marino M, Bersani C and Comi G. Antimicrobial activity of the essential oils of Thymus vulgaris L. measured using a bioimpedometric method. Journal of food protection, 1999; 62(9): 1017-1023.\u200f<\/li><li>Nolkemper S, Reichling J, Stintzing F. C, Carle R and Schnitzler P. Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitro. Plantamedica, 2006; 72(15): 1378-1382.<\/li><li>Youdim K. A and Deans S. G. Effect of thyme oil and thymol dietary supplementation on the antioxidant status and fatty acid composition of the ageing rat brain. British Journal of Nutrition, 2000; 83(1): 87-93.\u200f<\/li><li>Nickavar B, Mojab F and Dolat-Abadi R. Analysis of the essential oils of two Thymus species from Iran. Food chemistry, 2005; 90(4): 609-611.\u200f<\/li><li>El-Nekeety A. A, Mohamed S. R, Hathout A. S, Hassan N. S, Aly S. E and Abdel-Wahhab M. A. Antioxidant properties of Thymus vulgaris oil against aflatoxin-induce oxidative stress in male rats. Toxicon, 2011; 57(7-8): 984-991.\u200f<\/li><li>Amiri H. Essential oils composition and antioxidant properties of three thymus species. Evidence-Based Complementary and Alternative Medicine, 2012<\/li><\/ul><h2 class=\"wp-block-heading\"><strong><em>\u0627\u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0639\u0644\u0645\u064a \u0644\u0644\u0628\u0627\u0628\u0648\u0646\u062c:<\/em><\/strong><em><\/em><\/h2><h3 class=\"wp-block-heading\">\u062e\u0635\u0627\u0626\u0635 \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0648\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628<\/h3><p>\u062a\u062d\u062a\u0648\u064a \u0623\u0632\u0647\u0627\u0631 \u0627\u0644\u0628\u0627\u0628\u0648\u0646\u062c \u0639\u0644\u0649 1-2\u066a \u0632\u064a\u0648\u062a \u0645\u062a\u0637\u0627\u064a\u0631\u0629 \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 alpha-bisabolol \u0648 alpha-bisabolol oxides A &amp; B \u0648 matricin (\u0639\u0627\u062f\u0629\u064b \u0645\u0627 \u064a\u062a\u0645 \u062a\u062d\u0648\u064a\u0644\u0647 \u0625\u0644\u0649 Chamazulene \u0648 flavonoids \u0627\u0644\u0623\u062e\u0631\u0649 \u0627\u0644\u062a\u064a \u062a\u0645\u062a\u0644\u0643 \u062e\u0635\u0627\u0626\u0635 \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0648\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2995283\/#R12\">12<\/a>,&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2995283\/#R19\">19<\/a>,&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2995283\/#R35\">35<\/a>,&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2995283\/#R36\">36<\/a>) \u0623\u0638\u0647\u0631\u062a \u062f\u0631\u0627\u0633\u0629 \u0623\u062c\u0631\u064a\u062a \u0639\u0644\u0649 \u0645\u062a\u0637\u0648\u0639\u064a\u0646 \u0628\u0634\u0631\u064a\u064a\u0646 \u0623\u0646 \u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0641\u0644\u0627\u0641\u0648\u0646\u0648\u064a\u062f \u0648\u0627\u0644\u0632\u064a\u0648\u062a \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u062a\u062e\u062a\u0631\u0642 \u062a\u062d\u062a \u0633\u0637\u062d \u0627\u0644\u062c\u0644\u062f \u0641\u064a \u0637\u0628\u0642\u0627\u062a \u0627\u0644\u062c\u0644\u062f \u0627\u0644\u0639\u0645\u064a\u0642\u0629.<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2995283\/#R37\">37<\/a>\u0648\u0647\u0630\u0627 \u0645\u0647\u0645 \u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0643\u0639\u0648\u0627\u0645\u0644 \u0645\u0648\u0636\u0639\u064a\u0629 \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628 (\u0645\u0636\u0627\u062f \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a). \u0623\u062d\u062f \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0641\u064a \u0627\u0644\u0628\u0627\u0628\u0648\u0646\u062c. \u062a\u062a\u0636\u0645\u0646 \u0627\u0644\u0623\u0646\u0634\u0637\u0629 \u062a\u062b\u0628\u064a\u0637 \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u063a\u0644\u0627\u0646\u062f\u064a\u0646 E \u0627\u0644\u0646\u0627\u062c\u0645 \u0639\u0646 LPS \u0648\u062a\u062e\u0641\u064a\u0641 \u0646\u0634\u0627\u0637 \u0625\u0646\u0632\u064a\u0645 \u0627\u0644\u0623\u0643\u0633\u062f\u0629 \u0627\u0644\u062d\u0644\u0642\u064a\u0629 (COX-2) \u062f\u0648\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0639\u0644\u0649 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u062a\u0623\u0633\u064a\u0633\u064a \u060c COX-1 (38)<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2995283\/#R38\">38<\/a>)<\/p><p>12.&nbsp;Lemberkovics E, K\u00e9ry A, Marczal G, Sim\u00e1ndi B, Sz\u00f6ke E. 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\u0644\u0644\u0623\u0648\u0631\u0627\u0645:<\/strong><\/h2><p>\u0623\u0628\u0644\u063a \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0639\u0646 \u062e\u0635\u0627\u0626\u0635 \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0644\u0645\u0633\u062a\u062e\u0644\u0635 \u0623\u0648\u0631\u0627\u0642 \u0627\u0644\u0632\u064a\u062a\u0648\u0646 \u0641\u064a \u0646\u0645\u0648\u0630\u062c \u0633\u0631\u0637\u0627\u0646 \u062c\u0644\u062f \u0627\u0644\u062d\u064a\u0648\u0627\u0646. \u062a\u0633\u0628\u0628 \u0627\u0644\u0645\u0633\u062a\u062e\u0644\u0635 \u0641\u064a \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u060c \u0628\u062f\u0621\u064b\u0627 \u0645\u0646 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0628\u0631\u0645\u062c \u0627\u0644\u0645\u0628\u0643\u0631 \u0648\u0627\u0633\u062a\u0643\u0645\u0627\u0644\u064b\u0627 \u0628\u0627\u0644\u0646\u062e\u0631 \u0627\u0644\u062a\u0627\u0644\u064a<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5877547\/#B63-ijms-19-00686\">63<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5877547\/#B64-ijms-19-00686\">64<\/a>\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0628\u0648\u0644\u064a\u0641\u064a\u0646\u0648\u0644 \u0645\u0646 \u0645\u0633\u062a\u062e\u0644\u0635 \u0623\u0648\u0631\u0627\u0642 \u0627\u0644\u0632\u064a\u062a\u0648\u0646 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u062a\u0622\u0632\u0631\u064a\u0629 \u0639\u0646\u062f \u062f\u0645\u062c\u0647\u0627 \u0645\u0639 \u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u0642\u064a\u0627\u0633\u064a\u0629<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5877547\/#B63-ijms-19-00686\">63<\/a>]<p>\u0647\u0646\u0627\u0643 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0627\u062a\u062c\u0627\u0647\u0627\u062a \u0627\u0644\u0628\u0648\u0644\u064a\u0641\u064a\u0646\u0648\u0644 \u0632\u064a\u062a \u0627\u0644\u0632\u064a\u062a\u0648\u0646 \u060c \u0643\u0645\u0627 \u0644\u0648\u062d\u0638 \u0639\u0644\u0649 \u0627\u0644\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062c\u0632\u064a\u0626\u064a. \u0648\u0645\u0639 \u0630\u0644\u0643 \u060c \u064a\u0628\u062f\u0648 \u0623\u0646 \u0627\u0644\u0642\u062f\u0631\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0623\u0643\u0633\u062f\u0629 \u0644\u0632\u064a\u062a \u0627\u0644\u0632\u064a\u062a\u0648\u0646 \u0647\u064a \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0627\u0644\u0630\u064a \u064a\u0633\u0627\u0647\u0645 \u0641\u064a \u0627\u0644\u062d\u0645\u0627\u064a\u0629 \u0645\u0646 \u0627\u0644\u0633\u0631\u0637\u0627\u0646<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5877547\/#B72-ijms-19-00686\">72<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5877547\/#B73-ijms-19-00686\">73<\/a>].<\/p><p>\u0622\u0644\u064a\u0629 \u0639\u0645\u0644 \u0627\u0644\u0628\u0648\u0644\u064a\u0641\u064a\u0646\u0648\u0644 \u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0627\u062a\u062c\u0627\u0647\u0627\u062a \u060c \u0648\u0645\u0639 \u0630\u0644\u0643 \u060c \u0641\u0647\u064a \u062a\u062a\u0639\u0644\u0642 \u0641\u064a \u0627\u0644\u063a\u0627\u0644\u0628 \u0628\u0646\u0634\u0627\u0637\u0647\u0627 \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0644\u0623\u0643\u0633\u062f\u0629. \u064a\u0642\u0644\u0644 \u0627\u0644\u0628\u0648\u0644\u064a\u0641\u064a\u0646\u0648\u0644 \u0627\u0644\u0637\u0628\u064a\u0639\u064a \u0645\u0646 \u0645\u0633\u062a\u0648\u0649 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0643\u0633\u062c\u064a\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u0645\u064a \u0627\u0644\u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0645\u0646 \u0627\u0644\u0623\u0636\u0631\u0627\u0631 \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a\u0629. \u062a\u0645 \u0627\u0644\u0639\u062b\u0648\u0631 \u0639\u0644\u064a\u0647\u0627 \u0623\u064a\u0636\u064b\u0627 \u0644\u062a\u0639\u062f\u064a\u0644 \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u0628\u0634\u0631\u064a \u060c \u0645\u0645\u0627 \u064a\u0624\u062b\u0631 \u0639\u0644\u0649 \u062a\u0643\u0627\u062b\u0631 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645 \u0627\u0644\u0628\u064a\u0636\u0627\u0621 \u0648\u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0633\u064a\u062a\u0648\u0643\u064a\u0646\u0627\u062a<\/p><p>63.&nbsp;Mijatovic S.A., Timotijevic G.S., Miljkovic D.M., Radovic J.M., Maksimovic-Ivanic D.D., Dekanski D.P., Stosic-Grujicic S.D. 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